Project information
Image analysis in the study of mechanisms of induction, in diagnosis and for prevention of deleterious human diseases
- Project Identification
- VS97031
- Project Period
- 9/1997 - 12/2000
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Support to University Research Programmes
- MU Faculty or unit
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Faculty of Informatics
- prof. RNDr. Michal Kozubek, Ph.D.
- doc. RNDr. Irena Koutná, Ph.D.
- doc. RNDr. Pavel Matula, Ph.D.
- doc. RNDr. Petr Matula, Ph.D.
- RNDr. Petr Mejzlík, Dr.
- Ing. Magdalena Skalníková, CSc.
- doc. RNDr. Pavel Smrž, Ph.D.
- Mgr. Adriana Strejčková
- Keywords
- Chromatin structure, image analysis, cancer induction, optical microscopy
- Cooperating Organization
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Institute of Biophysics
- Responsible person Mgr. Alena Gaňová, Ph.D.
- Responsible person Mgr. Pavla Gajdušková, Ph.D.
- Responsible person Mgr. Andrea Marečková
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
- Responsible person Ing. Emilie Lukášová, CSc.
- Responsible person prof. RNDr. Eva Bártová, Ph.D., DSc.
- Responsible person Mgr. Jana Smejkalová, Ph.D.
- Responsible person MUDr. Eva Krahulcová, CSc.
A new laboratory for automated acquisition and on-line analysis of microscopic images will be established. The laboratory will be used for the investigation of the mechanisms of the induction of deleterious health diseases. The techniques of diagnostics and prevention will be also studied. The laboratory will be set up with the help of scientists from the Institute of Biophysics, ASCR. New methods of optical microscopy will be developed in collaboration with Oxford group. The image acquisition and analysis will be performed using the computing facilities of Faculty of Informatics, Masaryk University, particularly, the Supercomputing centre. The laboratory will be one of the first of such kind in the world. High-quality results on the chromatin structure, its changes and clinical significance are expected.
Publications
Total number of publications: 15
1999
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Chromatin structure and its cell cycle kinetics in intact and irradiated cell nuclei
Fundamentals for the assesment of risks from environmental radiation, year: 1999
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Chromosomes participating in translocations typical of malignant hemoblastoses are also involved in exchange aberrations induced by fast neutrons
Radiation Research, year: 1999, volume: 151, edition: 4
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The position of centromeres in interphase nuclei of human leukemic cells during myeloid differentiation and after gamma-irradiation
Fluorescence microscopy and fluorescent probes, year: 1999
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The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias
Chromosoma, year: 1999, volume: 108, edition: 7
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Topography of some genes and chromosomes in interphase nuclei of human cells
Fluorescence microscopy and fluorescent probes, year: 1999